Chemokine Class Differences in Binding to the Duffy Antigen-Erythrocyte Chemokine Receptor
نویسندگان
چکیده
منابع مشابه
From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen.
O phenotype and denoted as Fy(a0b0). When Duffy-negative individuals of African descent develop anti-Duffy alloantiNE OF THE MOST notable achievements of biomedical research in the first half of this century was the identification of red blood cell (RBC) antigens and the recogbodies, they are almost always anti-Fy rather than antiFy. The genotype designated FY/FY, which gives rise nition of the...
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OBJECTIVE Acute renal failure remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed as key components in the development of acute renal failure. Although the Duffy antigen receptor for chemokines (DARC) is present in several tissues and a highly specific ligand for various chemokines, its exact role in vivo remains unclear. DESIGN Prospective,...
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BACKGROUND The Duffy antigen receptor for chemokines (DARC) shows high affinity binding to multiple inflammatory CC and CXC chemokines and is expressed by erythrocytes and endothelial cells. Recent evidence suggests that endothelial DARC facilitates chemokine transcytosis to promote neutrophil recruitment. However, the mechanism of chemokine endocytosis by DARC remains unclear. METHODOLOGY/PR...
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Duffy gene (FY) codifies the transmembrane glycoprotein Duffy (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This glycoprotein is polymorphic, and constitutes the antigens of the Duffy histo-blood system which were designated receptors for chemokines and denominated DARC (Duffy antigen/receptor for chemokine). This receptor has an important role in the regulation of chemokine levels i...
متن کاملPotential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress.
CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or to transduce intracellular signals, although it is highly expressed on red blo...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.43.25348